As Jounce’s Vopratelimab Fails, Door Opens For LILRB2 Inhibitor JTX-8064

 
• By Alaric DeArment
  
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Vopratelimab is the second major ICOS agonist program to fail since GSK halted studies of feladilimab last year, but an analyst pinned higher hopes on JTX-8064.

Announcing SELECT's failure gives Jounce the chance to shift gears to JTX-8064 • Source: Shutterstock

The effort to develop drugs that target ICOS in oncology experienced yet another setback as one of the leading players in the space, Jounce Therapeutics, Inc., announced that the Phase II SELECT study of its ICOS agonist in non-small cell lung cancer failed to meet its primary endpoint. But while the trial failure marks a setback for the ICOS space overall, Jounce still has product candidates up its sleeve that hold out some promise.

Jounce announced the results of SELECT on 30 August, saying that the study did not show the requisite difference in...

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