BeiGene's Brukinsa PFS Win Lifts China Biotech Stocks

Bests Imbruvica In CLL

 
• By Dexter Jie Yan
  
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BeiGene's Brukinsa beats Imbruvica in top-line progression-free survival results from the Phase III head-to-head ALPINE trial in chronic lymphocytic leukemia or small lymphocytic lymphoma, marking the first time a rival BTK inhibitor has bested the same-class standard of care in this setting, and lifting the shares of other Chinese biotechs.

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Prospects of a China innovative drug outdoing a global rival help sharp rebound in Chinese biotech shares • Source: Shutterstock

A final analysis from the global, head-to-head Phase III ALPINE trial with Nasdaq-, Hong Kong- and Shanghai-listed BeiGene, Ltd.'s Bruton's tyrosine kinase (BTK) inhibitor Brukinsa (zanubrutinib) shows it beat Janssen Pharmaceuticals Inc./Pharmacyclics, Inc.’s same-class Imbruvica (ibrutinib) in terms of progression-free survival (PFS), a key secondary endpoint.

The study compared the two drugs in previously-treated patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic...

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