Tricida's Future In Doubt After Renal Outcomes Failure In CKD With Metabolic Acidosis

 
• By Jessica Merrill
  
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The company's hopes to bring veverimer to market to slow chronic kidney disease progression in patients with metabolic acidosis appear to be dashed.

end of the road
Tricida may have hit the end of the road with veverimer • Source: Shutterstock

Tricida, Inc.'s ambitions to bring the first drug to market to slow chronic kidney disease (CKD) progression in patients with metabolic acidosis appear have been derailed by a failure in a large renal outcomes trial. The company announced on 24 October that the VALOR-CKD renal outcomes study testing veverimer failed to meet the primary endpoint, apparently due to a high placebo response rate.

The announcement was a big setback for Tricida as veverimer is the company's sole clinical-stage development asset. An earlier Phase...

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