Esperion Hopes CVOT Will Help Drive Nexletol/Nexlizet’s Market Uptake

 
• By Alaric DeArment
  
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The drugs have been slow to catch on since approval more than two years ago, but results showing reduction in cardiovascular events could help it gain traction.

Esperion announced topline results from the CLEAR Outcomes trial • Source: Shutterstock

Esperion Therapeutics, Inc.’s cholesterol-lowering drugs Nexletol (bempedoic acid) and Nexlizet (bempedoic acid and ezetimibe) have been slow to gain market traction since winning US Food and Drug Administration approval in 2020, but the company has the opportunity to expand its presence with upcoming full results from its 14,000-patient Phase III cardiovascular outcomes trial (CVOT) in statin-intolerant patients.

Esperion announced top-line results, without full data, from the placebo-controlled CLEAR Outcomes trial on 7 December, stating that the study...

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