Madrigal Phase III Success In NASH Spurs Buyout Speculation

 
• By Joseph Haas
  
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With resmetirom hitting its co-primary endpoints, Madrigal intends to file the THRβ agonist for approval during H1 2023 in the liver disease, an unmet medical need with blockbuster earnings potential.

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Will Madrigal's Phase III NASH data lead to buyout offers? • Source: Shutterstock

Even though observers had widely expected some degree of success, Madrigal Pharmaceuticals, Inc. had an extremely good day on 19 December as it unveiled its long-anticipated Phase III data for resmetirom (MDGL-3196) in non-alcoholic steatohepatitis (NASH). The 955-patient Phase III MAESTRO-NASH study hit both of its primary endpoints, and as Madrigal announced plans to file resmetirom for accelerated approval during the first half of 2023, the firm’s stock price increased exponentially.

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