Aptinyx Pulls Back From Neuropsychiatry After Mid-Stage PD Failure

Prioritizes Cutting Costs

 
• By Ayisha Sharma
  
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The US firm has faced yet another clinical setback as its Phase II candidate, NYX-458, failed to improve cognitive impairment in patients with Parkinson’s disease and Alzheimer’s, triggering the cessation of its only other program as priorities shift to preserving funds.    

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The Parkinson's Failure Is The Fourth Clinical Setback In Recent Years • Source: Shutterstock

Aptinyx, Inc.’s future is looking increasingly uncertain after it experienced yet another clinical trial failure. Its hopes in the neuropsychiatry space have died following a Phase II flop in Parkinson’s disease (PD) and dementia, prompting the firm to wind down clinical activities for a separate post-traumatic stress disorder (PTSD) asset and focus on cutting costs amid a dwindling cash runway.

The Phase II trial set a 30mg dose of co-lead candidate NYX-458 against placebo for 12 weeks in 99 people...

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