FibroGen’s Roxadustat On The Rocks After Phase III Myelodysplastic Syndrome Failure

 
• By Alaric DeArment
  
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MATTERHORN’s failure did not surprise analysts, but it’s likely the end of the road for roxadustat in the US market. The focus instead has shifted to FibroGen’s IPF asset pamrevlumab.

FibroGen said 5 May that the Phase III study of roxadustat in MDS did not meet its primary endpoint • Source: Shutterstock

The failure of FibroGen, Inc.’s Phase III MATTERHORN trial of roxadustat in anemia among patients with transfusion-dependent lower-risk myelodysplastic syndrome (MDS) likely seals the drug’s fate in the US market, thereby shifting focus to pamrevlumab, FibroGen’s Phase III candidate for idiopathic pulmonary fibrosis (IPF). But IPF has been a challenging area of development.

FibroGen said 5 May that MATTERHORN, which enrolled 140 patients, did not met its primary endpoint measuring the proportion of...

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