Alnylam/Roche’s Zilebesiran Affirms Efficacy, But Commercially Relevant Data Await

 
• By Alaric DeArment
  
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The KARDIA-1 monotherapy study was successful, but KARDIA-2 will give a better sense of the market opportunity.

Alnylam announced results from the KARDIA-1 trial of zilebesiran • Source: Shutterstock

Alnylam Pharmaceuticals Inc.’s data from the Phase II KARDIA-1 study of its RNA interference drug zilebesiran affirm efficacy data published in July from a Phase I study, but data from another Phase II study, KARDIA-2, might better inform about the drug’s commercial opportunity. To that end, the company has partnered with Roche Holding AG and hopes to benefit from the Swiss drug maker’s buy-and-bill capabilities.

Alnylam announced the results of KARDIA-1, testing zilebesiran monotherapy against placebo in 394 patients, on 7 September. The trial met...

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