AbbVie’s Skyrizi Bests Stelara Head-To-Head In Crohn’s

 
• By Joseph Haas
  
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Data showing superiority on endoscopic remission and non-inferiority on clinical remission could position AbbVie’s IL-23 inhibitor to move ahead of Stelara in treatment paradigm.

Head to head
AbbVie's Skyrizi prevailed in a head-to-head trial versus Stelara • Source: Shutterstock

Already competing directly against Johnson & Johnson’s Stelara in psoriasis, psoriatic arthritis and Crohn’s disease, AbbVie Inc.’s Skyrizi notched a victory in the latter indication on 12 September, achieving non-inferiority on clinical remission and superiority on endoscopic remission in a Phase III head-to-head trial.

Key Takeaways

  • Skyrizi demonstrates non-inferiority for clinical remission and superiority for endoscopic remission in Crohn’s disease compared to J&J’s Stelara.

An IL-23 inhibitor that binds to the p19 subunit, Skyrizi brought in nearly $5.2bn in global sales in 2022 and...

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