CTAD 2023: Subcutaneous Leqembi Bests I.V., Could Open Access

At-Home Option An Important Growth Driver for Eisai/Biogen

 
• By Mandy Jackson
  
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The first results for subcutaneous lecanemab in early Alzheimer’s disease show better amyloid clearance with slightly higher ARIA rates than the I.V. version. Eisai also presented Phase III Clarity AD updates and initial long-term extension data.

Alzheimer's disease, Amyloid plaques aggregates, 3d illustration
Amyloid plaque clearance was 14% greater with subcutaneous Leqembi • Source: Shutterstock

Once-weekly subcutaneous injections of Eisai Co., Ltd./Biogen, Inc.’s Leqembi (lecanemab) provided 14% greater amyloid plaque clearance at six months in patients with early Alzheimer’s disease than the US Food and Drug Administration-approved I.V. version of the amyloid protofibril-targeting antibody administered every two weeks. Eisai will submit 12-month results in a biologics license application (BLA) seeking FDA approval for the subcutaneous version by the end of March 2024.

Key Takeaways

  • Subcutaneous Leqembi provided greater amyloid plaque clearance and patients had 11% more exposure to the drug compared with the I.V. version.

Eisai presented the first results for subcutaneous Leqembi on 25 October at the Clinical Trials on Alzheimer’s Disease (CTAD) meeting...

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