Placebo Response Hurts MoonLake In Psoriatic Arthritis

 
• By Elizabeth Cairns
  
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Sonelokimab follows a mid-stage slam-dunk in hidradenitis suppurativa with a rather more equivocal result in a different immune condition in the ARGO study.    

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Investors wondering why MoonLake Immunotherapeutics AG’s press release covering the Phase II findings on sonelokimab in psoriatic arthritis omitted the figures for the placebo group got their answer on a call today. The placebo response of 20% on the trial’s primary endpoint sorely hurt the IL-17 inhibitor’s apparent efficacy.

Key Takeaways

  • Phase II trial succeeded, but placebo response was high

That said, the Phase II ARGO trial still succeeded, with statistically significantly more patients treated with sonelokimab achieving an American...

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