Dupixent Heralds The Age Of Biologics In COPD

 
• By Elizabeth Cairns
  
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A second pivotal hit positions Sanofi and Regeneron’s antibody for approval in COPD – but other biologics are coming fast.

Molecular model of an antibody
• Source: Shutterstock/Kateryna Kon

The results of Dupixent’s first pivotal chronic obstructive pulmonary disease (COPD) trial were good; the results of the second look even better. Top-line data from the Phase III NOTUS trial showed a significant 34% reduction in exacerbations over placebo at one year, beating the 30% seen in the identical BOREAS trial back in March (Also see "Dupixent Succeeds Where Other Biologic Drugs Failed – In COPD" - Scrip, 23 March, 2023.).

Key Takeaways
  • The second of Dupixent’s Phase III COPD trials has hit even more emphatically than the first

Sanofi and Regeneron Pharmaceuticals, Inc. will take the data from both trials to regulators by the end of...

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