Inventiva Craters On NASH Safety Scare

 
• By Elizabeth Cairns
  
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An adverse reaction in lanafibranor’s Phase III trial leaves the company even more reliant on the upcoming LEGEND readout.   

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With the approval of Madrigal Pharmaceuticals, Inc.’s resmetirom in non-alcoholic steatohepatitis (NASH) in less than a month all but assured, Inventiva S.A. was one of two groups contesting the second-place position. Now the silver medal looks likely to go to Novo Nordisk A/S; Inventiva has had to pause enrolment in the NATiV3 trial of its candidate, lanifibranor, following a suspected adverse reaction.

Key Takeaways

  • Enrollment of the Phase III NATiV3 trial has been paused, delaying the readout until mid-2026

This is a serious setback, and Inventiva’s market cap has taken a 17% hit as investors drove its share price...

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