Tremfya Shows Head-To-Head Edge Versus Stelara In Crohn’s

 
• By Joseph Haas
  
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Johnson & Johnson tested Tremfya against its established Stelara as the “benchmark” in IBD. Tremfya, already up for approval in ulcerative colitis, is planned for filing in Crohn’s later in 2024.

Johnson & Johnson plans to submit a US filing for supplemental approval in Crohn’s disease for Tremfya before the end of 2024, a plan bolstered by Phase III data demonstrating head-to-head superiority to the firm’s older drug Stelara, but on the market J&J will also have to contend with AbbVie Inc.’s Skyrizi, which analysts say offers better efficacy in Crohn’s.

Key Takeaways

  • J&J is seeking to add IBD indications to the Tremfya label as Stelara nears biosimilar competition. A head-to-head Phase III trial showed superiority for Tremfya over the older drug in Crohn’s.

Tremfya (guselkumab) and Skyrizi (risankizumab) are IL-23 inhibitors, while Stelara blocks both IL-12 and IL-23. With Stelara (ustekinumab) expected to...

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