ASCO: AstraZeneca Achieves Eye-Catching Solid Tumor Results With 'Armored' CAR-T

 
• By Andrew McConaghie
  
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Solid tumor CAR-T may succeed AZD7003 where many others have failed as the firm builds its cell therapy pipeline.

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The ASCO conference was once again held at McCormick Place in Chicago. • Source: Shutterstock

Numerous attempts to make CAR-Ts work in solid tumors have failed in recent years, but AstraZeneca has caught attention this week with promising Phase I data for its candidate, C-CAR031 (AZD7003), presented at the American Society of Oncology meeting in Chicago.

Key Takeaways

  • Early results from the ‘armored’ CAR-T could end long-running failure against solid tumors

AstraZeneca is collaborating with the Chinese biotech AbelZeta to develop the GPC3 protein-targeting therapy which uses a novel "armored" construct....

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