Takeda’s Soticlestat Fails In Seizure Trials

 
• By Jessica Merrill
  
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Two Phase III studies testing soticlestat, licensed from Ovid, in Dravet and Lennox-Gastaut syndromes failed to meet their primary endpoints on improvement in seizure frequency.

Missed target
Two of Takeda's Phase III studies missed the primary endpoint • Source: Shutterstock

Takeda Pharmaceutical Co. Ltd.’s late-stage candidate soticlestat (TAK-975) failed in two Phase III clinical trials for convulsive seizures, a setback in what is already poised to be a challenging year for the Japanese pharma.

Key Takeaways

  • Soticlestat failed to show a significant benefit in frequency of convulsive seizures in two different pediatric epilepsies, refractory Dravet syndrome and Lennox-Gastaut syndrome.

The company announced on 17 June that soticlestat failed to show a significant benefit in frequency of convulsive seizures in...

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