Alnylam’s Amvuttra Market May See Tenfold Increase After Phase III Win

 
• By Alaric DeArment
  
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The company posted positive results from the HELIOS-B trial in patients with ATTR-CM, which represents a much larger population than the approved hATTR-PN indication.

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Alnylam Pharmaceuticals Inc. stands to significantly increase the addressable population for Amvuttra (vutrisiran) with positive Phase III data in patients with ATTR amyloidosis with cardiomyopathy (ATTR-CM). However, without detailed data from the clinical trial, the commercial prospects remain unclear given the lengthened follow-up in the study and the increasingly competitive market.

The Cambridge, MA-based biotech announced topline results from the HELIOS-B study in ATTR-CM on 24 June, stating that the study...

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