CalciMedica Eyes Success In Pancreatitis, Acute Kidney Injury

 
• By Joseph Haas
  
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Phase IIb data for Auxora in an acute pancreatitis subpopulation is expected to set up the CRAC channel inhibitor for Phase III in that indication while suggesting positive read-through for AKI.

Pancreatitis
CalciMedica hopes Auxora can be the first US drug therapy for acute pancreatitis • Source: Shutterstock

CalciMedica, Inc.’s positive top-line Phase IIb data for Auxora (CM4620) in acute pancreatitis with accompanying systemic inflammatory response syndrome (SIRS) should position the calcium release-activated calcium (CRAC) channel inhibitor to move into Phase III in an unmet medical need, the company said. In addition, the biotech thinks the data clarified the specific patient population and dosing for a pivotal trial and should offer positive read-through to an ongoing Phase II study of Auxora in acute kidney injury (AKI).

Key Takeaways

  • CalciMedica intends to advance CRAC channel inhibitor Auxora into Phase III for unmet medical need acute pancreatitis following Phase IIb success.

Based in La Jolla, CA, CalciMedica has been a pioneer in the CRAC channel inhibitor space and advanced Auxora to...

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