Sage NMDA Modulator Fails In Alzheimer’s Months After Parkinson’s Disappointment

 
• By Joseph Haas
  
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Dalzanemdor missed its primary endpoint in a Phase II Parkinson’s study, Sage announced, following April’s Phase II miss in Alzheimer’s. Phase II data in Huntington’s are still expected this year.

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The misses keep on coming for Sage Therapeutics with dalzanemdor, its oral positive allosteric modulator (PAM) of the NMDA receptor, which failed to hit the primary and exploratory endpoints in a Phase II study in Alzheimer’s disease patients, but the biotech said on 8 October that it holds out hope for success with the drug in a Phase II Huntington’s disease trial.

Key Takeaways

  • Sage’s dalzanemdor fails a Phase II study in Alzheimer’s cognitive impairment, six months after the drug missed in a Phase II study in Parkinson’s disease.

In the 174-patient LIGHTWAVE study in Alzheimer’s, dalzanemdor (SAGE-718) failed to meet statistical significance versus placebo on the Weschler Adult...

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