Lilly/Pfizer’s Tanezumab Safety Takes A Hit With Latest Phase III Results

 
• By Joseph Haas
  
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Larger of two doses of the NGF inhibitor hit two efficacy endpoints, but the rate of joint health outcomes on a composite measure was higher than control by a statistically significant margin.

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Lilly and Pfizer's latest clinical data for tanezumab did not de-risk the drug's safety

Eli Lilly & Co. and Pfizer Inc.’s efforts to revive the prospects of tanezumab – and with it the safety-troubled nerve growth factor (NGF) inhibitor class – endured another setback, as the two pharmas reported that while their drug hit two of three efficacy endpoints in a 16-week analysis in osteoarthritis patients, an 80-week safety assessment showed worrisome indications of disease worsening compared to control.

In top-line data released after the markets closed April 18, Lilly and Pfizer said a 5 mg dose of tanezumab...

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